Research

Our goal in pediatric neurological research is to find the best methods for treating disorders of the brain and nervous system in children. We are committed to discovering the best ways to care for kids.

Our research partners include

• Children's Foundation Research Institute (CFRI)
• St. Jude Children’s Research Hospital
• Semmes Murphey Neurologic and Spine Institute
•  The University of Tennessee Health Science Center (UTHSC)

Our Research

• Medication: Our epileptologists are studying cognitive outcomes in children with partial seizures. Their work will broaden our understanding of how medications affect pediatric patients.
• Brain mapping: Our clinical neuroscience team is leading the way in research of non-invasive functional neuroimaging techniques in children.
• Better outcomes: We’re constantly looking for innovative ways to provide better outcomes for children. We’ve documented a reduced need for reoperation or repeat sedation for postoperative scans in children by utilizing the intraoperative MRI (iMRI).
• Expanding knowledge on rare conditions: Le Bonheur works with other centers to gather data to better understand complex neurological conditions.

For more information on our studies, read our physician publication, Brain Waves.

Clinical Trials

If you are interested in participating in a neuroscience clinical trial, please view our list of current and active trials.

Recent Publications

• "Consensus-Based Evaluation of Outcome Measures in Pediatric Stroke Care: A Toolkit" Pediatric Neurology
• "Primary Diffuse Leptomeningeal Glioneuronal Tumor Presenting as Bilateral Vision Loss" Journal of Neuro-Ophthalmology 
• "Long-Term Cannabidiol Treatment for Seizures in Patients with Tuberous Sclerosis Complex: An Open-Label Extension Trial" Epilepsia
• "Sudden Unexpected Death in Epilepsy (SUDEP): How Do We Prevent This Childhood Tragedy?" Journal of Pediatric Pharmacology and Therapeutics 
• "Safety Evaluation of Perampanel as Monotherapy or First Adjunctive Therapy in Patients with Epilepsy" Expert Opinion on Drug Safety
• "Image-Guided TMS Is Safe in a Predominately Pediatric Clinical Population" Clinical Neurophysiology 
• "Surgical Approaches to Intramedullary Spinal Cord Astrocytomas in the Age of Genomics" Frontiers in Oncology 
• "Pre-Operative Embolization for Staged Treatment of Infantile Choroid Plexus Papilloma" Child's Nervous System
• "Managing Acute Seizures: New Rescue Delivery Option and Resources to Assist School Nurses" NASN School Nurse
• "Serial Assessment of Measurable Residual Disease in Medulloblastoma Liquid Biopsies" Cancer Cell